Starting year 2022

Chubu University
Department of Biomedical Sciences, College of Life and Health Sciences / Center for Mathematical Science and Artificial Intelligence / Center for Clinical Examination Practicum Support
Associate Professor

Research Areas:Life Science
Manufacturing Technology (Mechanical Engineering, Electrical and Electronic Engineering, Chemical Engineering)
Natural Science

Research fields

Medical engineering
Information science

Research Interests

Heart Physiology
Contraction Rhythm Homeostasis
Sarcomere Chaos
Real-time Electron Microscopy
Pre-illness Diagnosis

Professional Memberships

Biophysical Society (U.S.A.)
The Biophysical Society of Japan
The Physiological Society of Japan
The Japanese Society of Microscopy
Japanese Society for Chronobiology
Japan Society for Cell Biology
Society of Nano Science and Technology

Main research topics

Summary: I am researching how nanoscale biomolecules produce robust heartbeat rhythms. I found that myocardium uses the heat of body temperature to create a contractile rhythm that combines chaotic instability and homeostatic stability (figure). And I got a mathematical model prediction that its contractile rhythm characteristics are important for rapid ventricular dilation with each dilation of the heart. It is strongly suggested that this result may lead to pre-illness diagnosis and preemptive medical care for heart disease, and I am currently conducting research with this exit orientation.

Hyperthermal sarcomeric oscillations (HSOs): I have discovered that by warming myocardial cells to about body temperature, sarcomeres inside cardiomyocytes become HSOs, which repeatedly contract and relax in a cycle close to the heartbeat. Interestingly, HSOs kept their cycle constant despite their sensitive changes in amplitude and waveform under the influence of changes in intracellular calcium concentration. Furthermore, HSOs have found that the amplitude and phase are chaotically changed in order to achieve both responsiveness and stability.

Electron microscope live imaging method (DET film method): We have developed a technology for observing the structure and “movement” of submerged samples such as wet organs as they are with a scanning electron microscope. This measurement is possible by creating and using a thin film (DET film: Deformable and Electron Transmissive Film) that can withstand the pressure difference between vacuum and atmospheric pressure and has excellent electron beam permeability and deformability. Currently, I am conducting research and development toward the realization of observation and measurement of various nanoscale dynamics.

Representative papers

Seine A. Shintani., Seiji Yamaguchi and Hiroaki Takadama, Real-Time Scanning Electron Microscopy of Unfixed Tissue in Solution using a Deformable and Electron-Transmissive Film., Microscopy, dfac030, 2022.

Seine A. Shintani., Hyperthermal sarcomeric oscillations generated in warmed cardiomyocytes control amplitudes with chaotic properties while keeping cycles constant., Biochemical and Biophysical Research Communications, 611, 8-13, 2022.

Research URL


Interview article of Chubu University

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