SHINTANI A. Seine
Contraction Rhythm Homeostasis
Real-time Electron Microscopy
Biophysical Society (U.S.A.)
The Biophysical Society of Japan
The Physiological Society of Japan
The Japanese Society of Microscopy
Japanese Society for Chronobiology
Japan Society for Cell Biology
Society of Nano Science and Technology
Main research topics
Summary: I am researching how nanoscale biomolecules produce robust heartbeat rhythms. I found that myocardium uses the heat of body temperature to create a contractile rhythm that combines chaotic instability and homeostatic stability (figure). And I got a mathematical model prediction that its contractile rhythm characteristics are important for rapid ventricular dilation with each dilation of the heart. It is strongly suggested that this result may lead to pre-illness diagnosis and preemptive medical care for heart disease, and I am currently conducting research with this exit orientation.
Hyperthermal sarcomeric oscillations (HSOs): I have discovered that by warming myocardial cells to about body temperature, sarcomeres inside cardiomyocytes become HSOs, which repeatedly contract and relax in a cycle close to the heartbeat. Interestingly, HSOs kept their cycle constant despite their sensitive changes in amplitude and waveform under the influence of changes in intracellular calcium concentration. Furthermore, HSOs have found that the amplitude and phase are chaotically changed in order to achieve both responsiveness and stability.
Electron microscope live imaging method (DET film method): We have developed a technology for observing the structure and “movement” of submerged samples such as wet organs as they are with a scanning electron microscope. This measurement is possible by creating and using a thin film (DET film: Deformable and Electron Transmissive Film) that can withstand the pressure difference between vacuum and atmospheric pressure and has excellent electron beam permeability and deformability. Currently, I am conducting research and development toward the realization of observation and measurement of various nanoscale dynamics.
Seine A. Shintani.⁎, Seiji Yamaguchi and Hiroaki Takadama, Real-Time Scanning Electron Microscopy of Unfixed Tissue in Solution using a Deformable and Electron-Transmissive Film., Microscopy, dfac030, 2022.
Seine A. Shintani.⁎, Hyperthermal sarcomeric oscillations generated in warmed cardiomyocytes control amplitudes with chaotic properties while keeping cycles constant., Biochemical and Biophysical Research Communications, 611, 8-13, 2022.
Interview article of Chubu University https://www.chubu.ac.jp/chubuly-style/757/
NEDO Research Seeds Introduction https://wakasapo.nedo.go.jp/seeds/seeds-1839/
Press release of recent research results 1 https://www.chubu.ac.jp/news/5561/
Press release of recent research results 2 https://www.chubu.ac.jp/news/3240/
T-GEx Associate Dr. Seine A. Shintani, Lecturer, Chubu University, has been certificated as INNO-β, the Strategic Information and Communications R&D Promotion Programme(SCOPE) of the Ministry of Internal Affairs and Communications.
T-GEx Associate Dr. Seine A. Shintani, Lecturer, Chubu University, received the Best Poster Award at the 29th Annual Meeting of the Japanese Society for Chronobiology.
T-GEx Associate Dr. Seine A. Shintani, Lecturer, Chubu University, received a prize at the Company Participation Pitch Contest co-organised by the Annual Meeting of The Biophysical Society of Japan.
The paper of T-GEx Associate Dr. Seine A. Shintani, Senior Assistant Professor, Chubu University, has been ranked No. 1 in the most read ranking in the international journal of Microscopic Science “Microscopy”.
An interview article by T-GEx Associate Dr. Seine A. Shintani, Senior Assistant Professor ,Chubu University, was published in The Mainichi Shimbun.
A paper by T-GEx Associate Dr. Seine A. Shintani, Lecturer, Chubu University, was published in Microscopy.